Anniversary and Special Issues

Hypoxia and Reproductive Health

The January 20201 issue of Reproduction contains a special editorial on hypoxia and reproduction guest edited by Dr Jacqueline Maybin.

This editorial comprises seven diverse reviews exploring how varying oxygen levels can change reproductive biology from the non-pregnant reproductive system, through early pregnancy, foetal development and delivery.

Each review gives a comprehensive overview of current knowledge, and signposts areas for future research in the rapidly evolving field of hypoxia and reproduction.

Explore this special issue:


Hypoxia and reproductive health. Jacqueline A Maybin


The presence and role of hypoxia in the endometrium. Rocío Martínez-Aguilar, Lucy E Kershaw, Jane J Reavey, Hilary O D Critchley, and Jacqueline A Maybin

The role of hypoxia in the development and progression of endometriosis. Wan-Ning Li, Meng-Hsing Wu, and Shaw-Jenq Tsai

Hypoxia and ovarian function: follicle development, ovulation, oocyte maturation. Megan Lim, Jeremy G Thompson, and Kylie R Dunning

Hypoxic regulation of preimplantation embryos: lessons from human embryonic stem cells. Franchesca D Houghton

Oxygen and development of the human placenta. Graham J Burton, Tereza Cindrova-Davies, Hong wa Yung, and Eric Jauniaux

Hypoxia and labour. Susan Wray, Mona Alruwaili, and Clodagh Prendergast

Reproductive challenges at high altitude: fertility, pregnancy and neonatal well-being. Lorna G Moore

Watch this video from Guest Editor, Jacqueline Maybin

30 years of pre-implantation genetic testing

The November 2020 issue of Reproduction includes special content on pre-implantation genetic testing, which is guest edited by Professor Alan Handyside, who reported the first pregnancies using this technique in Nature in 1990. The special content includes an Editorial from Professor Handyside, followed by five free-to-read reviews, from authors including Laurent Tellier, Joris Robert Bermeesch and Kathelijn Keymolen.

Explore the special content:

EDITORIAL: 30 years of preimplantation genetic testing. Alan H Handyside.

REVIEW: Non-invasive prenatal testing for aneuploidy, copy-number variants and single-gene disorders. J Shaw, E Scotchman, N Chandler, and L S Chitty.

REVIEW: Preimplantation genetic testing for polygenic disease risk. Nathan R Treff, Diego Marin, Louis Lello, Stephen Hsu, and Laurent C A M Tellier.

REVIEW: Single-cell technologies at the forefront of PGT and embryo research. Olga Tšuiko, Elia Fernandez Gallardo, Thierry Voet, and Joris Robert Vermeesch.

REVIEW: Chromosome abnormalities in human embryos. Carmen Rubio, Lorena Rodrigo and Carlos Simón.

REVIEW: Clinical experience of preimplantation genetic testing Martine De Rycke, Veerle Berckmoes, Anick De Vos, Stefanie Van De Voorde, Pieter Verdyck, Willem Verpoest, and Kathelijn Keymolen.


Watch this video from the Guest Editor, Professor Alan Handyside


IVF Special Issue, guest edited by Lord Robert Winston

The July 2018 issue of Reproduction marked the 40th anniversary of the first birth of a baby conceived by in vitro fertilisation. The issue is guest edited by Lord Robert Winston who, in his editorial, expresses concerns that advances in the field of reproductive medicine may be being hampered by a lack of fundamental academic research, which may be a result of regulatory bureaucracy.

The issue contains seven free-to-read anniversary reviews:

Low-dose gonadotropin induction of ovulation in anovulatory women: still needed in the age of IVF

Davinia M White, Kate Hardy, Suzannah Lovelock, and Stephen Franks

Female fertility preservation: past, present and future

Benjamin Fisch and Ronit Abir

Chromosomal analysis in IVF: just how useful is it?

Darren K Griffin and Cagri Ogur

Development of ICSI

C L O’Neill, S Chow, Z Rosenwaks, and G D Palermo

In vitro follicle culture in the context of IVF

Anamaria C Herta, Francesca Lolicato, and Johan E J Smitz

‘Designer babies’ almost thirty years on

Alan H Handyside

Previous Anniversary Issues

Anniversary Issue: 25th birthday of intracytoplasmic sperm injection

This issue is guest edited by Gianpiero Palermo and Claire O'Neill. You can read their editorial here.

Gianpiero Palermo has recorded a short video discussing the success of ICSI since its inception and looking toward the future of assisted reproductive technology.

The anniversary reviews that make up the special issue are:

Publication of Sex in 3 Cities Review

Richard M Sharpe, who gave the 2017 Sex in 3 Cities lecture series, has published a review article based on the content of his talks.

The article, entitled “Programmed for sex: Nutrition-reproduction relationships from an inter-generational perspective”, encourages readers to consider reproduction as a long-term investment whereby nature has evolved epigenetic regulatory mechanisms that enable the rapid adaptation of offspring to their perceived nutritional environment.

Read the review here.


30 years of interferon-tau

Professor Michael Roberts is the guest editor of Reproduction’s anniversary issue commemorating 30 years of interferon-tau.

Read Professor Roberts’ editorial here.

Professor Roberts has also kindly recorded a video linked to this anniversary issue that can be viewed below.

Anniversary Reviews comprising the anniversary issue:

The evolution of interferon-tau by Alan D Ealy and Lydia K Wooldridge

Chronicling the discovery of interferon tau by Fuller W Bazer and William W Thatcher

Transcriptional control of IFNT expression by Toshihiko Ezashi and Kazuhiko Imakawa

Interferon-tau and fertility in ruminants by N Forde and P Lonergan

Paracrine and endocrine actions of interferon tau (IFNT) by Thomas R Hansen, Leticia D P Sinedino, and Thomas E Spencer